Caspase 8 Antibody 54 Publications

Rabbit Polyclonal| Catalog number: 13423-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 70 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HepG2 cells, UV treated Hela , RAW264.7 , Raji cells, HeLa cells, Staurosporine treated Jurkat cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human lymphoma tissue, human colon tissue, human lymphoma tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
caspase 8, apoptosis-related cysteine peptidase

Calculated molecular weight:
538aa,62 kDa

Observed molecular weight:
50-55 kDa,25-32 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CASP8

Synonyms
Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, FADD like ICE, FLICE, ICE like apoptotic protease 5, MCH5
Background

CASP8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. CASP8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816 ). It may control diabetic embryopathy-associated apoptosis via regulation of the Bid-stimulated mitochondrion/caspase-9 pathway(PMID:19194987). CASP8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. 13423-1-AP can recognize the pro- and cleaved-caspase 8.


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