|Positive IHC detected in||human tonsillitis tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive FC detected in||K-562 cells|
|Immunohistochemistry (IHC)||IHC : 1:400-1:1600|
|Sample-dependent, check data in validation data gallery|
The immunogen of 17476-1-AP is CCR5 Fusion Protein expressed in E. coli.
|Cited Reactivity||human, Indian rhesus macaques|
|Host / Isotype||Rabbit / IgG|
|Immunogen||CCR5 fusion protein Ag11493|
|Full Name||chemokine (C-C motif) receptor 5|
|Calculated molecular weight||352 aa, 41 kDa|
|GenBank accession number||BC038398|
|Gene ID (NCBI)||1234|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
CCR5 (also known as CD195) is a member of the beta chemokine receptor family. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. The natural chemokine ligands that bind to CCR5 include MIP-1-alpha, MIP-1-beta, MCP-2 and RANTES.
Lack of susceptibility in neonatally infected rhesus macaques to simian immunodeficiency virus-induced encephalitis.
Prog Neuropsychopharmacol Biol Psychiatry
CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4+ T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4+ T cell enrichment in humanized mice.
J Biol Chem
Regulation of C-C chemokine receptor 5 (CCR5) stability by Lys197 and by transmembrane protein aptamers that target it for lysosomal degradation.