CUL4B-Specific Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 16184-1-AP

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Freight/Packing

Con: 16 μg/150 μl

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Tested Applications

Applications:
ELISA
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Species specificity:
human, mouse, rat

Recommended dilution:

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
cullin 4B

Calculated molecular weight:
104 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CUL4B

Synonyms
Background

Cullin-RING ligases (CRLs) complexes participate in the regulation of diverse cellular processes, including cell cycle progression, transcription, signal transduction and development (PMID: 21816341)(PMID: 21554755). Serving as the scaffold protein, cullins are crucial for the assembly of ligase complexes, which recognize and target various substrates for proteosomal degradation. Two cullin 4 (CUL4) proteins, CUL4A (87 kDa) and CUL4B(104 kDa), are two members in cullin family with 83% of identity. Mutations in human CUL4B are one of the major causes of X-linked mental retardation. Cul4b knockout mice demonstrated that CUL4B is indispensable for embryonic development in the mouse (PMID: 22606329). Proteintech's CUL4B antibody 16184-1-AP is specifically against CUL4B but not CUL4A.


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