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C-X-C motif chemokine 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that is encoded by the CXCL10 gene. CXCL10 is a small cytokine belonging to the CXC chemokine family and may be a key mediateor of Interfern-gamma response. CXCL10 (1-73) is produced by proteolytic cleavage after secretion from keratinocytes. Serum concentration of CXCL10 are augmented in both newly diagnosed Type I diabetes and subjects at risk of developing in the disease. CXCL10 also may be a candidate gene in patients with Alzheimer’s disease.