|Positive WB detected in||mouse heart tissue, HepG2 cells, human heart tissue, human skeletal muscle tissue, MCF-7 cells, mouse skeletal muscle tissue, rat testis tissue|
|Positive IHC detected in||human breast cancer tissue, human heart tissue, human lung tissue, human ovary tissue, human placenta tissue, human skin tissue, human spleen tissue, human testis tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||MCF-7 cells|
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
10676-1-AP targets FABP3 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||FABP3 fusion protein Ag1069|
|Full Name||fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)|
|Calculated molecular weight||15 kDa|
|Observed molecular weight||15 kDa|
|GenBank accession number||BC007021|
|Gene ID (NCBI)||2170|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
FABP3 (fatty-acid-binding protein 3), also known as heart-type FABP or mammary-derived growth inhibitor (MDGI), is a small 15-kDa cytoplasmic protein transporting fatty acids and other lipophilic substances from the cytoplasm to the nucleus. It is most ubiquitously expressed in heart and skeletal muscle.
Downregulations of placental fatty acid transporters during cadmium-induced fetal growth restriction.
Cell Death Dis
Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure.
Cell Death Discov
Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization.
J Biol Chem
J Biol Chem
FABP3 promotes αSyn oligomerization associated with MPTP-induced neurotoxicity.