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  • KD/KO Validated

Fibrinogen Gamma Chain Polyclonal antibody

Fibrinogen Gamma Chain Polyclonal Antibody for IHC, WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF, ELISA

Conjugate

Unconjugated

Cat no : 15841-1-AP

Synonyms

FGG, fibrinogen gamma chain



Tested Applications

Positive WB detected inhuman spleen tissue, human liver tissue
Positive IHC detected inhuman hepatocirrhosis tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:10000
Immunohistochemistry (IHC)IHC : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

15841-1-AP targets Fibrinogen Gamma Chain in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Fibrinogen Gamma Chain fusion protein Ag8597
Full Name fibrinogen gamma chain
Calculated molecular weight453aa,52 kDa; 437aa,50 kDa
Observed molecular weight 52 kDa
GenBank accession numberBC007044
Gene symbol FGG
Gene ID (NCBI) 2266
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA), beta (FGB), gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing, and neoplasia (PMID: 16102057). FGG is the gamma chain of fibrinogen. Mutations in the gene of FGG lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.

Protocols

Product Specific Protocols
WB protocol for Fibrinogen Gamma Chain antibody 15841-1-APDownload protocol
IHC protocol for Fibrinogen Gamma Chain antibody 15841-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
ratWB

Neurochem Int

Quantitative iTRAQ-based proteomic analysis of piperine protected cerebral ischemia/reperfusion injury in rat brain.

Authors - Yichun Zou
humanWB,IHC,IF

Front Neurosci

Fibrinogen Chains Intrinsic to the Brain.

Authors - Eugene V Golanov
  • KD Validated
ratIHC

J Neurotrauma

FTY720 Attenuates Neuropathic Pain after Spinal Cord Injury by Decreasing Systemic and Local Inflammation in a Rat Spinal Cord Compression Model.

Authors - Kazuyoshi Yamazaki
humanWB

Sci Rep

C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1.

Authors - Anika Alberts
mouse

J Thromb Haemost

Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) cross-linking via tissue transglutaminase.

Authors - L G Poole
human,ratIHC,IF

Blood

Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury.

Authors - Krishnamoorthy Aparna A