FRS2 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66263-1-Ig |CloneNo.: 4E10H12

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Freight/Packing

Con: 224 μg/150 μl

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Species specificity:
human

Positive WB detected in:
MCF-7 cells, HEK-293 cells, HeLa cells

Positive IHC detected in:
human prostate cancer tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG3

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
fibroblast growth factor receptor substrate 2

Calculated molecular weight:
60 kDa

Observed molecular weight:
68 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FRS2

Synonyms
FGFR signaling adaptor SNT, FGFR substrate 2, FRS2, FRS2A, FRS2alpha, SNT, SNT 1, SNT1
Background

Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) has an alternative name as SNT-1, it is an adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. FRS2 is a 508 amino-acid protein,which is phosphorylated on tyrosine residues. The molecular weight of non-phosphorylated FRS2 is 57-68 kDa, but phosphorylated FRS2 is 80-90 kDa. Phosphorylation of FRS2 is associated with activation of a number of MAP kinases. Allele-specific regulation of FGFR2 mRNA expression with a mildly increased breast cancer risk has been reported.


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