GRIN2B Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 21920-1-AP

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Freight/Packing

Con: 57 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, human brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human brain tissue

Positive IF detected in:
SH-SY5Y cells

Positive FC detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB
IHC : 1:50-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Calculated molecular weight:
1484aa,166 kDa

Observed molecular weight:
166 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GRIN2B

Synonyms
GluN2B, GRIN2B, hNR3, NMDAR2B, NR2B, NR3
Background

GRIN2B (also known as GluN2B or NMDAR2B) is a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. NMDA receptors are widely expressed in the central nervous system and play a major role in excitatory synaptic transmission and plasticity (PMID: 23223336). NMDA receptors large multi-subunit complexes arranged into heteromeric assemblies composed of four homologous subunits within a repertoire of over 10 different subunits: eight GluN1 isoforms, four GluN2 subunits (A-D) and two GluN3 subunits (A and B) (PMID: 21395862). Naturally occurring mutations within GRIN2B gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.


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