HLA-G Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 16913-1-AP

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Freight/Packing

Con: 40 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human placenta tissue

Recommended dilution:
WB : 1:1000-1:4000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
major histocompatibility complex, class I, G

Calculated molecular weight:
338aa,38 kDa

Observed molecular weight:
33-45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HLA-G

Synonyms
HLA 6.0, HLA G, HLA G antigen, HLAG, HLA-G, MHC class I antigen G, MHC G
Background

Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). HLA-G is a non-classical MHC class I molecule with multiple immunoregulatory properties. HLA-G exhibits a restricted pattern of expression that includes placental extravillous trophoblasts at the maternal-fetal interface, where it abolishes maternal immune cell activity against fetus and establishes immune tolerance. Aberrant expression of HLA-G has been found in a variety of human neoplastic diseases. It plays an important role in the escape of tumor cells from immunosurveillance.


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