IDH1 Antibody 17 Publications

Rabbit Polyclonal| Catalog number: 12332-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 25 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
mouse liver tissue, DU 145 cells, HEK-293 cells, HeLa cells, HepG2 cells, MCF-7 cells, mouse liver tissue, mouse pancreas tissue, mouse small intestine tissue, NIH/3T3 cells, rat liver tissue

Positive IP detected in:
MCF-7 cells

Positive IHC detected in:
human gliomas tissue, human gliomas tissue, human kidney tissue, human liver cancer tissue, human lung tissue, human placenta tissue, human skin tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:100
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
isocitrate dehydrogenase 1 (NADP+), soluble

Calculated molecular weight:
414aa,47 kDa

Observed molecular weight:
47 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IDH1

Synonyms
IDCD, IDH, IDH1, IDP, IDPC, NADP(+) specific ICDH, Oxalosuccinate decarboxylase, PICD
Background

IDH1, also named as PICD and IDP, belongs to the isocitrate and isopropylmalate dehydrogenases family. It is a common feature of a major subset of primary human brain cancers. It can form a homodimer(PMID:15173171).IDH1 mutation is always heterozygotic and IDH1 functions as a dimer, theoretically there will be 25% each wild type and mutant homo-dimers and 50% hetero-dimers present in the tumor cells(PMID:21079649 ).


Back
to top