Iduronate 2 sulfatase Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66112-1-Ig |CloneNo.: 1A3F9

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Con: 78 μg/150 μl

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Species specificity:
human, mouse, rat , pig

Positive WB detected in:
Human placenta,rat brain tissue, human brain tissue, mouse brain tissue, pig brain tissue

Positive IHC detected in:
human liver tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Purification method:
Protein G purification


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
iduronate 2-sulfatase

Calculated molecular weight:
312aa,35 kDa;550aa,62 kDa

Observed molecular weight:
76 kDa, 55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

IDS, iduronate 2 sulfatase, Idursulfase

Iduronate 2-sulfatase (IDS) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations causing IDS deficiency in humans result in the lysosomal storage of these glycosaminoglycans and Hunter syndrome, an X chromosome-linked disease. IDS is synthesized as two precursor forms of 76 and 90 kDa that are converted, through a 62 kDa intermediate, to 55 and 45 kDa mature polypeptides due to an internal proteolytic cleavage (PMID: 10838181).

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