IFITM3 Antibody 32 Publications

Rabbit Polyclonal| Catalog number: 11714-1-AP

Featured Product KD/KO validated

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Con: 59 μg/150 μl

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Species specificity:
human, mouse, rat, goat

Positive WB detected in:
mouse colon tissue, HeLa cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human lung cancer tissue, human colon cancer tissue

Positive IF detected in:
HeLa cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:3000 for WB
IHC : 1:50-1:400
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
interferon induced transmembrane protein 3 (1-8U)

Calculated molecular weight:
133aa,15 kDa

Observed molecular weight:
14 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IFITM3

Synonyms
1 8U, Fragilis, IFITM3, IP15
Background

IFITM3, also named as interferon-inducible protein 1-8U, belongs to the CD225 family. It is IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus, by inhibiting the early steps of replication. IFITM3 is identified as interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. IFITM3, the most potent antiviral IFITM, was found to inhibit an uncharacterized early infectious event after VSV endocytosis, but before primary transcription of its viral genome. IFITM proteins are viral restriction factors that can inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. They differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression. Catalog#11714-1-AP is a rabbit polyclonal antibody raised against the full-length of human IFITM3.


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