NeutraKine® IL-12/IL-23 p40 Monoclonal antibody

NeutraKine® IL-12/IL-23 p40 Monoclonal Antibody for Neutralization, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse

Applications

Neutralization, ELISA

Conjugate

Unconjugated

CloneNo.

2A9H6

Cat no : 69006-1-Ig

Synonyms

Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40), IL 23, IL-12 subunit p40, IL-12/IL-23 p40, IL12B, IL-12B, IL-23 p40, IL23A, IL-23B, IL23P19, NeutraKine® IL-23 p40, SGRF



Neutralization

Product Information

69006-1-Ig targets NeutraKine® IL-12/IL-23 p40 in Neutralization, ELISA applications and shows reactivity with Human, mouse samples.

Tested Reactivity Human, mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen human Humankine IL-12/IL-23 p40 protein HZ-1254
Full Name interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Calculated molecular weight 328 aa, 37 kDa
GenBank accession numberBC067498
Gene symbol IL12B
Gene ID (NCBI) 51561,3593
RRIDAB_2882924
Conjugate Unconjugated
Form Lyophilized Powder
Purification Method Protein G purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Background Information

IL-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).

This antibody can be used to neutralize the bioactivity of IL-12/IL-23 p40.