IL-6 Antibody 33 Publications

Rabbit Polyclonal| Catalog number: 21865-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 53 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
Recombinant protein, mouse spleen tissue, Transfected HEK-293 cells

Positive IHC detected in:
human tonsillitis tissue, human hepatocirrhosis tissue, human spleen tissue, human tonsillitis tissue

Recommended dilution:
WB : 1:1000-1:6000
IHC : 1:50-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
interleukin 6 (interferon, beta 2)

Calculated molecular weight:
212aa,24 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IL6

Synonyms
B cell stimulatory factor 2, BSF 2, BSF2, CDF, CTL differentiation factor, HGF, HSF, Hybridoma growth factor, IFN beta 2, IFNB2, IL 6, IL6, IL-6, Interferon beta 2, Interleukin 6
Background

Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 Plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.


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