c-Met (Cytoplasmic) Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 25869-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 43 μg/150 μl

Choose size:

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Species specificity:
human, rat

Positive WB detected in:
A431 cells,HepG2 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human colon tissue, human liver cancer tissue

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
met proto-oncogene (hepatocyte growth factor receptor)

Calculated molecular weight:
1390aa,155 kDa

Observed molecular weight:
145 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MET

Synonyms
AUTS9, c-Met, HGF receptor, HGF/SF receptor, HGFR, MET, Proto oncogene c Met, RCCP2, Scatter factor receptor, SF receptor, Tyrosine protein kinase Met
Background

c-Met (also named as MET or HGFR) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. c-Met regulates many physiological processes including proliferation, scattering, morphogenesis and survival. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Overexpression and/or mutation of c-Met has been reported in various human malignancies, including lung cancer, breast cancer, head and neck cancer, gastric cancer, colorectal cancer, bladder cancer, uterine cervix carcinoma, and esophageal carcinoma, c-Met could serve as an important therapeutic target (PMID: 26036285). The c-met receptor is a 190-kD glycoprotein consisting of a 145-kD membrane-spanning beta chain and a 50-kD alpha chain (PMID: 7806559).


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