|Positive IHC detected in||human lung cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
14650-1-AP targets MPP3 in IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||MPP3 fusion protein Ag6246|
|Full Name||membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)|
|Calculated molecular weight||66 kDa|
|GenBank accession number||BC056865|
|Gene ID (NCBI)||4356|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.1% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
MPP3, also named as DLG3, belongs to the MAGUK family which interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. MPP3 plays an important role in signal transduction.
PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.
MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex.