NBR1 Antibody 11 Publications

Rabbit Polyclonal| Catalog number: 16004-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 61 μg/150 μl

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Species specificity:
human, mouse, rat, monkey

Positive WB detected in:
HeLa cells, A2780 cells, COS-7 cells, HeLa cells, HepG2 cells, Jurkat cells, MCF-7 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human heart tissue, human skeletal muscle tissue

Positive IF detected in:
Hela cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
neighbor of BRCA1 gene 1

Calculated molecular weight:
966aa,107 kDa

Observed molecular weight:
140 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NBR1

Synonyms
1A1 3B, 1A13B, FLJ55359, FLJ98272, KIAA0049, M17S2, MIG19, NBR1, neighbor of BRCA1 gene 1, Next to BRCA1 gene 1 protein, Protein 1A1 3B
Background

NBR1, also named as 1A13B, KIAA0049 and M17S2, acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. NBR1 and P62 can bind to autophagic effector proteins (Atg8 in yeast, MAP1LC3 protein family in mammals) anchored in the membrane of autophagosomes. It is a highly conserved multidomain scaffold protein with proposed roles in endocytic trafficking and selective autophagy. NBR1 is a novel PB1 adapter in Th2 differentiation and asthma. It functions as an autophagy receptor involved in targeting ubiquitinated proteins for degradation. It also has a dual role as a scaffold protein to regulate growth-factor receptor and downstream signaling pathways.


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