NF200 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60331-1-Ig |CloneNo.: 1A3C7

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Freight/Packing

Con: 225 μg/150 μl

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Species specificity:
human, pig

Positive WB detected in:
pig brain tissue

Positive IHC detected in:
human brain tissue

Positive IF detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:1000-1:8000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
neurofilament, heavy polypeptide

Calculated molecular weight:
112 kDa

Observed molecular weight:
200 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NEFH

Synonyms
Background

NEFH, also named as KIAA0845 and NFH, Belongs to the intermediate filament family. It has an important function in mature axons that is not subserved by the two smaller NF proteins. Neurofilaments are the 10nm intermediate filaments found specifically in neurons. They are a major component of the cell's cytoskeleton, and provide support for normal axonal radial growth. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The names given to the three major neurofilament subunits are based upon the apparent molecular weight of the mammalian subunits on SDS-PAGE:NF-L, 65-68kd; NF-M,145-160kd and NF-H, 200-220kd. This antibody recognize NEFH only.


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