Pyruvate Carboxylase Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 16588-1-AP

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Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat, pig

Positive WB detected in:
HepG2 cells

Positive IP detected in:
mouse liver tissue

Positive IHC detected in:
human liver tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
pyruvate carboxylase

Calculated molecular weight:
1178aa,130 kDa

Observed molecular weight:
125-130kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PC

Synonyms
PC, PCB, pyruvate Carboxylase, Pyruvic carboxylase
Background

PC(pyruvate carboxylase) is a member of the family of biotin-dependent carboxylases and is found widely among eukaryotic tissues and in many prokaryotic species. It catalyses the ATP-dependent carboxylation of pyruvate to form oxaloacetate which may be utilised in the synthesis of glucose, fat, some amino acids or their derivatives and several neurotransmitters. Diabetes and hyperthyroidism increase the level of expression of pyruvate carboxylase in the long term, while its activity in the short term is controlled by the intramitochondrial concentrations of acetyl-CoA and pyruvate(PMID:9597748).


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