PD-1/CD279 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 18106-1-AP

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Freight/Packing

Con: 38 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HEK-293 cells, K-562 cells, mouse spleen tissue

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human tonsillitis tissue, human lymphoma tissue, human ovary tumor tissue

Positive IF detected in:
human tonsillitis tissue

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2400
IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB
IHC : 1:100-1:400
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
programmed cell death 1

Calculated molecular weight:
288aa,32 kDa

Observed molecular weight:
47-55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PDCD1

Synonyms
CD279, hPD 1, hPD l, PD 1, PD1, PD-1, PDCD1, programmed cell death 1, Protein PD 1, SLEB2
Background

Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436). It has been reported that PD-1 is heavily glycosylated and migrates with an apparent molecular mass of 47-55 kDa on SDS-PAGE , which is larger than its predicted mass of 32 kDa (PMID: 8671665; 17640856; 17003438).


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