PPP3CA Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 13422-1-AP

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Con: 75 μg/150 μl

Choose size:

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Species specificity:
human, mouse

Positive WB detected in:
mouse skeletal muscle tissue, mouse heart tissue, SH-SY5Y cells

Positive IP detected in:
mouse heart tissue

Positive IHC detected in:
human colon cancer tissue, human cervical cancer tissue

Positive IF detected in:
SH-SY5Y cells

Positive FC detected in:
HeLa cells,

Recommended dilution:
WB : 1:1000-1:8000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Purification method:
Antigen affinity purification


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform

Calculated molecular weight:
511aa,61 kDa

Observed molecular weight:
59 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

Calcineurin A alpha, CALN, CALNA, CALNA1, CAM PRP catalytic subunit, CCN1, CNA, CNA1, PPP2B, PPP3CA

PPP3CA, also called calcineurin Aα, is the only serine/threonine protein phosphatase under the control of Ca2+/calmodulin, and plays a critical role in the coupling of Ca2+ signals to cellular responses. Ca2+ signaling plays a central role in hypertrophic growth of cardiac and skeletal muscle in response to mechanical load and a variety of signals. Therefore, PPP3CA plays an important role in muscle differentiation, especially in muscle fiber type conversion. It is also involved in osteoclast regulation, regulating bone formation through an effect on osteoblast differentiation.

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