PPP3CA Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 13422-1-AP

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Freight/Packing

Con: 75 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse skeletal muscle tissue, mouse heart tissue, SH-SY5Y cells

Positive IP detected in:
mouse heart tissue

Positive IHC detected in:
human colon cancer tissue,human cervical cancer tissue

Positive IF detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:1000-1:8000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform

Calculated molecular weight:
511aa,61 kDa

Observed molecular weight:
59 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PPP3CA

Synonyms
Calcineurin A alpha, CALN, CALNA, CALNA1, CAM PRP catalytic subunit, CCN1, CNA, CNA1, PPP2B, PPP3CA
Background

PPP3CA, also called calcineurin Aα, is the only serine/threonine protein phosphatase under the control of Ca2+/calmodulin, and plays a critical role in the coupling of Ca2+ signals to cellular responses. Ca2+ signaling plays a central role in hypertrophic growth of cardiac and skeletal muscle in response to mechanical load and a variety of signals. Therefore, PPP3CA plays an important role in muscle differentiation, especially in muscle fiber type conversion. It is also involved in osteoclast regulation, regulating bone formation through an effect on osteoblast differentiation.


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