SMN Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 20451-1-AP

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Freight/Packing

Con: 46 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HEK-293 cells,Jurkat cells, HepG2 cells, K-562 cells

Positive IP detected in:
HEK-293

Positive IHC detected in:
human kidney tissue,human heart tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
survival of motor neuron 2, centromeric

Calculated molecular weight:
282aa,30 kDa

Observed molecular weight:
38 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SMN2

Synonyms
C BCD541, Component of gems 1, FLJ76644, Gemin 1, SMN, SMN1, SMN1,SMN, SMN2, SMNC, SMNT, Survival motor neuron protein
Background

Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of anterior horn cells in the spinal cord and concomitant symmetrical muscle weakness and atrophy (PMID: 16364894 ). SMA is caused by deletion or mutations of the survival motor neuron (SMN1) gene. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional (PMID: 17355180). A large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein (PMID: 10369862). The level of SMN protein correlates with phenotypic severity of SMA.


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