SMN (Human,Mouse,Rat) Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60154-2-Ig |CloneNo.: 3C10B5

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Con: 150 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
A375 cells

Positive IF detected in:
HEK-293 cells

Recommended dilution:
WB : 1:1000-1:6000
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
survival of motor neuron 2, centromeric

Calculated molecular weight:
282aa,30 kDa

Observed molecular weight:
38 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SMN2

Synonyms
C BCD541, Component of gems 1, FLJ76644, Gemin 1, SMN, SMN1, SMN1,SMN, SMN2, SMNC, SMNT, Survival motor neuron protein
Background

The survival of motor neurons (SMN) genes are the disease genes of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The level of SMN protein correlates with phenotypic severity of SMA. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional, because a large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein. This antibody 60154-2-Ig can recognize human,mouse and rat SMN gene.


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