SP1 Antibody 12 Publications

Rabbit Polyclonal| Catalog number: 21962-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 30 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, A431 cells, HEK-293 cells, Jurkat cells, K-562 cells

Positive IP detected in:
A431 cells

Positive IHC detected in:
human lung cancer tissue, human colon tissue, human stomach cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Sp1 transcription factor

Calculated molecular weight:
785aa,81 kDa

Observed molecular weight:
95-106 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SP1

Synonyms
SP1, Sp1 transcription factor, Transcription factor Sp1, TSFP1
Background

The transcription factor Sp1 is a C2H2 zinc-finger protein that is involved in the regulation of a wide variety of genes, including housekeeping genes and tumor-developing genes. It is associated with tumor development, growth, and metastasis [PMID: 16209919]. It regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Besides, it has a role in modulating the cellular response to DNA damage, recruiting SMARCA4/BRG1 on the c-FOS promoter, regulation of FE65 gene expression [PMID:11371615,16332679]. SP1 has some isoforms with MW ~95-106 kDa and ~60 kDa [PMID:17462816].


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