STIM1 Antibody 17 Publications

Rabbit Polyclonal| Catalog number: 11565-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 63 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, BxPC-3 cells, HT-1080 cells, mouse liver tissue, NIH/3T3 cells, Raji cells

Positive IP detected in:
Raji cells

Positive IHC detected in:
human ovary tumor tissue, human lung cancer tissue, human ovary tumor tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
stromal interaction molecule 1

Calculated molecular weight:
685aa, 77 kDa

Observed molecular weight:
80-90 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
STIM1

Synonyms
D11S4896E, GOK, STIM1, stromal interaction molecule 1
Background

STIM1, also named as GOK, is an ER Ca2+ sensor. Upon Ca2+ store depletion, STIM1 clusters at ER–plasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca(2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms. Catalog#11565-1-AP is rabbit polyclonal antibody raised against the N-terminal of human STIM1.


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