TDP-43 (full length) Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 18280-1-AP

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Freight/Packing

Con: 38 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, human heart tissue, K-562 cells

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human gliomas tissue, human gliomas tissue, mouse brain tissue, rat brain tissue

Positive IF detected in:
HeLa cells

Positive FC detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:3000 for WB
IHC : 1:20-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
TAR DNA binding protein

Calculated molecular weight:
43 kDa

Observed molecular weight:
43 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TARDBP

Synonyms
ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43
Background

Transactivation response (TAR) DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43) was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U). 18280-1-AP is a rabbit polyclonal antibody raised against the full-length of human TDP-43. This antibody recognizes the cleavage product of 20-30 kDa in addition to the native and phosphorylated forms of TDP-43. Immunohistochemical analyses of TDP-43 using this antibody detect both normal diffuse nuclear staining and insoluble inclusions in pathologic tissues.


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