TNF-alpha Antibody 26 Publications

Rabbit Polyclonal| Catalog number: 17590-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Tested Applications

Applications:
ELISA, IHC, WB
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Species specificity:
human, mouse, chicken, rat

Recommended dilution:

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
tumor necrosis factor (TNF superfamily, member 2)

Calculated molecular weight:
233aa,26 kDa

Observed molecular weight:
26 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TNF

Synonyms
Cachectin, DIF, TNF, TNF a, TNF alpha, TNFA, TNFSF2, TNFα, Tumor necrosis factor
Background

TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.


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