VAMP2 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 10135-1-AP

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Con: 43 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, fetal human brain tissue

Positive IHC detected in:
human skeletal muscle tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
vesicle-associated membrane protein 2 (synaptobrevin 2)

Calculated molecular weight:
13 kDa

Observed molecular weight:
19 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VAMP2

Synonyms
FLJ11460, SYB2, Synaptobrevin 2, VAMP 2, VAMP2
Background

VAMP2 (vesicle-associated membrane protein 2), also named as synaptobrevin 2, is a member of the SNARE (soluble NSF-attachment protein receptor) family proteins. Characterized by a common sequence called the SNARE motif, SNARE proteins are involved in membrane fusion and vesicular transport (PMID: 11252968). VAMP2, with a molecular mass of 15-19kDa, consists of a short N-terminal sequence, a SNARE motif, and a C-terminal transmembrane region. It is required for fast calcium-triggered synaptic vesicle fusion. VAMP2 forms a stable complex with STX1 (syntaxin 1) and SNAP25 (synaptosomal-associated protein 25) during synaptic vesicle fusion (PMID: 16793874). It also forms a distinct complex with synaptophysin. VAMP2 is expressed in nervous system and some non-neuronal tissues, such as skeletal muscle (PMID: 18570252).


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