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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human IL-17F

Activity

Typically ≤ 10 ng/mL EC50

Species Reactivity

Human

Purity

>95%

Cat no : HZ-1116

Synonyms

IL 17F, IL17F



Technical Specifications

GeneID 112744
Species Human
Expression HEK293
Activity Typically ≤ 10 ng/mL EC50
Purity >95%
Molecular Mass 38 kDa, homodimer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Animal-free Recombinant Human IL-17F is a homodimeric glycoprotein with an apparent molecular mass of 38 kDa. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, which contributes to stability in cell growth media and other applications. IL-17 is commonly associated with allergic responses. IL-17 induces the production of many other cytokines (such as IL-6, G-CSF, GM-CSF, IL-1beta, TGF beta, and TNF alpha), chemokines (including IL-8, GRO alpha, and MCP-1), and prostaglandins (e.g., PGE2) from many cell types (fibroblasts, endothelial cell, epithelial cells, keratinocytes, and macrophages). The release of cytokines causes many functions, such as airway remodeling, a characteristic of IL-17 responses.

Background

IL-17F is a homodimeric glycoprotein with an apparent molecular mass of 38 kDa. IL-17 is commonly associated with allergic responses. IL-17 induces the production of many other cytokines such as TNF alpha, chemokines such as IL-8 and prostaglandins. The IL17-induced release of cytokines has many effects, including airway remodeling in asthma (PMID 24292568)

Synonyms

IL 17F, IL17F