ALADIN Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 15127-1-AP

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Freight/Packing

Con: 73 μg/150 μl

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Species specificity:
human, monkey

Positive WB detected in:
SH-SY5Y cells, HeLa cells

Positive IHC detected in:
human stomach cancer tissue

Positive IF detected in:
COS-7 cells, Hela cells

Recommended dilution:
WB : 1:500-1:2400
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A)

Calculated molecular weight:
60 kDa

Observed molecular weight:
60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AAAS

Synonyms
AAA, AAAS, AAASb, ADRACALA, ADRACALIN, ALADIN, DKFZp586G1624, GL003
Background

The AAAS gene product is the 60 kDa nuclear pore complex (NPC) protein alacrima-achalasia-adrenal insufficiency neurological disorder (ALADIN). AAAS mRNA and the ALADIN protein are ubiquitously expressed with predominance in the adrenal and central nervous system structures in human and rat. ALADIN, a Tryptophan-Aspartic acid (WD) repeat containing protein, was the first nuclear pore complex protein to be associated with hereditary neurodegenerative disease and the only nuclear pore complex protein to be associated with hereditary adrenal disease. ALADIN's precise function at the nuclear pore complex is unknown. Most naturally occurring AAAS mutations result in mislocalization of the abnormal ALADIN protein (mainly into the cytoplasm), implying that correct NPC targeting is vital for its function. (PMID: 23825130)


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