ACVRL1 Monoclonal antibody
ACVRL1 Monoclonal Antibody for IHC, WB, ELISA
Host / Isotype
Mouse / IgG1
Cat no : 66857-1-Ig
Validation Data Gallery
|Positive WB detected in
|HUVEC cells, Daudi cells, human placenta tissue, JAR cells, Jurkat cells, mouse brain tissue
|Positive IHC detected in
|human lymphoma tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)
|WB : 1:1000-1:6000
|IHC : 1:150-1:600
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
66857-1-Ig targets ACVRL1 in WB, IHC applications and shows reactivity with Human, Mouse samples.
|Host / Isotype
|Mouse / IgG1
|ACVRL1 fusion protein Ag6446
|activin A receptor type II-like 1
|Calculated molecular weight
|Observed molecular weight
|56 kDa, 63 kDa
|GenBank accession number
|Gene ID (NCBI)
|Protein A purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
ACVRL1 (also known as ALK1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1 is highly expressed in endothelial cells and has a critical role in the control of blood vessel development and repair (PMID: 8640225). Mutations in the ACVRL1 gene are associated with hemorrhagic telangiectasia type 2.