ARG1 Antibody 1 Publications

Mouse Monoclonal| Catalog number: 66129-1-Ig |CloneNo.: 5D6D12

Featured Product KD/KO validated

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 150 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, pig, rat, mouse

Positive WB detected in:
HepG2 cells, pig liver tissue, rat liver tissue, RAW 264.7 cells

Positive IHC detected in:
human liver cancer tissue, human liver tissue, human liver cancer tissue

Recommended dilution:
WB : 1:1000-1:8000
IHC : 1:200-1:1000

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
arginase, liver

Calculated molecular weight:
236aa,25 kDa;322aa,35 kDa

Observed molecular weight:
36 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ARG1

Synonyms
ARG1, Arginase 1, liver Arginase, Liver type arginase
Background

Arginase-1 (Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology and a marker of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation(PMID:12098359) and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins(PMID: 20071539).It can exsit as a homotrimer(PMID:16141327) and it has 3 isoforms produced by alternative splicing.Defects in ARG1 are the cause of argininemia (ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control.(PMID:27117406). ARG1 is a novel biomarker of post-stroke immune suppression(2016).


Back
to top