BLOC1S2 Polyclonal antibody
BLOC1S2 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
ELISA
Conjugate
Unconjugated
Cat no : 12165-1-AP
Synonyms
Validation Data Gallery
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
12165-1-AP targets BLOC1S2 in ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | BLOC1S2 fusion protein Ag2807 |
Full Name | biogenesis of lysosomal organelles complex-1, subunit 2 |
Calculated Molecular Weight | 142 aa, 16 kDa |
GenBank Accession Number | BC020494 |
Gene Symbol | BLOC1S2 |
Gene ID (NCBI) | 282991 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
BLOS2, also named BLOC1S2, is a shared subunit of two lysosomal trafficking complexes, biogenesis of lysosome-related organelles complex-1 (BLOC-1) and BLOC-1 related complex. Loss of BLOS2 resulted in elevated Notch signaling which consequently increased the proliferation of neural progenitor cells and inhibited neuronal differentiation in cortices. BLOS2 is a novel negative player in regulating Notch signaling through lysosomal trafficking by controlling multiple stem and progenitor cell homeostasis in vertebrates. (PMID 27719760)