BMP2 Polyclonal antibody

• Featured Product
• KD/KO Validated

BMP2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (4)

Applications

WB, IHC, IF, ELISA

Conjugate

Unconjugated

Publications

53

Cat no : 18933-1-AP

Synonyms

BMP 2, BMP 2A, BMP2, BMP-2, BMP2A, bone morphogenetic protein 2, Bone morphogenetic protein 2A

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Validation Data Gallery

• 

  WB analysis of HeLa using 18933-1-AP

  HeLa cells were subjected to SDS PAGE followed by western blot with 18933-1-AP (BMP2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: HeLa cells

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000

Sample-dependent, check data in validation data gallery

Published Applications

• KD/KO: See 2 publications below
• WB: See 46 publications below
• IHC: See 12 publications below
• IF: See 6 publications below

Product Information

The immunogen of 18933-1-AP is BMP2 Fusion Protein expressed in E. coli.

• Tested Reactivity: human
• Cited Reactivity: human, mouse, rat, hamster, sheep
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: BMP2 fusion protein Ag13501
• Full Name: bone morphogenetic protein 2
• Calculated molecular weight: 396 aa, 44 kDa
• GenBank accession number: BC069214
• Gene symbol: BMP2
• Gene ID (NCBI): 650
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor-beta (TGFB) superfamily. BMP2 is synthesized as a 60 kDa precursor that is processed in the secretory pathway to a small 18 kDa monomer; 2 monomers then associate to form the active 30 kDa homodimer, which binds to its receptor. There is also a 40-45 kDa form of BMP2, as an amino-terminal propeptide. BMP2 can induce bone formation and regeneration during early embryonic development. It is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction.

Publications

Species	Application	Title
rat	WB,IHC	Biomaterials; Guided bone regeneration is promoted by the molecular events in the membrane compartment.; Authors - Alberto Turri
human	WB	Carbohydr Polym; A fucoidan from Nemacystus decipiens disrupts angiogenesis through targeting bone morphogenetic protein 4.; Authors - Wucheng Wang
rat	WB	Arterioscler Thromb Vasc Biol; Overexpression of c1q/tumor necrosis factor-related protein-3 promotes phosphate-induced vascular smooth muscle cell calcification both in vivo and in vitro.; Authors - Yun Zhou
rat	WB，IHC	Antioxid Redox Signal; Role of Nox4 in high calcium-induced renal oxidative stress damage and crystal deposition.; Authors - Yang Xun
human	WB	Free Radic Biol Med; Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.; Authors - Wen-Qi Ma
mouse	WB	Development; Postnatal eye size in mice is controlled by SREBP2-mediated transcriptional repression of Lrp2 and Bmp2.; Authors - Shuyi Mai

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