BMP2 Antibody 11 Publications

Rabbit Polyclonal| Catalog number: 18933-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 24 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, HL-60 cells, HT-1080 cells, mouse lung tissue, PC-13 cells, Sp2/0 cells

Positive IHC detected in:
human small intestine tissue, human colon tissue, human heart tissue, human lung tissue, human small intestine tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
bone morphogenetic protein 2

Calculated molecular weight:
396aa,44 kDa

Observed molecular weight:
45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BMP2

Synonyms
BMP 2, BMP 2A, BMP2, BMP2A, bone morphogenetic protein 2, Bone morphogenetic protein 2A
Background

Bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor-beta (TGFB) superfamily. BMP2 is synthesized as a 60 kDa precursor that is processed in the secretory pathway to a small 18 kDa monomer; 2 monomers then associate to form the active 30 kDa homodimer, which binds to its receptor. There is also a 40-45 kDa form of BMP2, as an amino-terminal propeptide. BMP2 can induce bone formation and regeneration during early embryonic development. It is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction.


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