Product Information
28136-1-PBS targets Caspase 14 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag27242 Product name: Recombinant human CASP14 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-242 aa of BC069541 Sequence: MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRLYLQ Predict reactive species |
| Full Name | caspase 14, apoptosis-related cysteine peptidase |
| Calculated Molecular Weight | 242 aa, 28 kDa |
| Observed Molecular Weight | 35 kDa |
| GenBank Accession Number | BC069541 |
| Gene Symbol | CASP14 |
| Gene ID (NCBI) | 23581 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P31944 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Caspase14 belongs to the caspase family of cysteinyl aspartate-specific proteinases that frequently play a central role in apoptosis. Caspase14 exist as inactive proenzymes that undergo proteolytic processing to produce large and small subunits (p20 and p10) at Ile152/Lys153 residues, which is different to other caspases (Asp residue). Caspase14 plays a role in protein maturation of filaggrin, and possibly in DNA repair. Overexpression of Caspase14 has been detected in several of epithelial malignancies, indicating that Caspase14 could play a role in carcinogenesis and disease progression of cancers. Caspase14 can binds the apoptosis-inducing factor (AIF) indicating that caspase14 may be an anti-apoptotic protein. In the LADC specimens, two bands can be detected with MW of 35 kDa and 37 kDa which represent Caspase14 and the phosphorylated Caspase14(pCasp-14) respectively. (PMID:21567094, 12200134, 10203698, 17515931, 16061209). This antibody can recognise all the forms of Caspase14.
