|Positive FC detected in
|human monocyte-derived dendritic cells cells, IL-4 and IL-13-stimulated THP-1-derived macrophages
|This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 10 µl per 10^6 cells in a 100 µl suspension or 10 µl per 100 µl of whole blood.
|Sample-dependent, check data in validation data gallery
PE-65155 targets CD206 in FC applications and shows reactivity with Human samples.
|Host / Isotype
|Mouse / IgG1, kappa
|Purified human mannose receptor
|mannose receptor, C type 1
|Calculated molecular weight
|GenBank accession number
|Gene ID (NCBI)
|PE Fluorescent Dye
|Excitation/Emission maxima wavelengths
|496 nm, 565 nm / 578 nm
|The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
|PBS with 0.1% sodium azide.
|Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.
CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.
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