B7-H3 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66481-1-Ig |CloneNo.: 1E7D1

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Con: 150 μg/150 μl

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Species specificity:
Human, Pig

Positive WB detected in:
HEK-293 cells

Positive IHC detected in:
human tonsillitis tissue, human placenta tissue, human prostate cancer tissue, human lung cancer tissue

Recommended dilution:
WB : 1:1000-1:6000
IHC : 1:375-1:1500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CD276 molecule

Calculated molecular weight:
57 kDa

Observed molecular weight:
100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CD276

Synonyms
4Ig B7 H3, B7 homolog 3, B7-H3, CD276, CD276 antigen, CD276 molecule, Costimulatory molecule, UNQ309/PRO352
Background

B7-H3 (CD276) is a type I transmembrane protein expressed on many tissues and cell types. B7-H3 belongs to the B7 immunoregulatory family and participate in the regulation of T-cell-mediated immune response probably by functioning as both a T cell costimulator and coinhibitor (PMID: 20696859). Overexpressed on a wide range of human solid cancers, B7-H3 has been implicated in cancer progression and metastasis and becomes an attractive target for cancer immunotherapy (PMID: 27208063).


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