Validation Data Gallery
|Sample-dependent, check data in validation data gallery|
12877-1-AP targets p15 INK4b in WB,ELISA applications and shows reactivity with human samples.
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||p15 INK4b fusion protein Ag3557|
|Full Name||cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)|
|Calculated molecular weight||138 aa, 15 kDa|
|GenBank accession number||BC014469|
|Gene ID (NCBI)||1030|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Dis Model Mech
A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal.
NRF2-regulated cell cycle arrest at early stage of oxidative stress response mechanism.
Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice.
Cell proliferation downregulated by TGF-β2-triggered G1/S checkpoint in clinical CAFs.
MYC promotes cancer progression by modulating m6 A modifications to suppress target gene translation.
CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A.