|Positive WB detected in||Jurkat cells|
|Positive IHC detected in||human spleen tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:200-1:1000|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
The immunogen of 17192-1-AP is CFP Fusion Protein expressed in E. coli.
|Host / Isotype||Rabbit / IgG|
|Immunogen||CFP fusion protein Ag9798|
|Full Name||complement factor properdin|
|Calculated molecular weight||469 aa, 51 kDa|
|Observed molecular weight||50 kDa|
|GenBank accession number||BC015756|
|Gene ID (NCBI)||5199|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
CFP, also named as Properdin or CFP, is a 469 amino acid protein, which contains 7 TSP type-1 domains. CFP as secreted protein is a positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Properdin deficiency poses a significant risk for severe meningococcal infections (PMID: 22229731). Properdin may be novel biomarker for future risk of type 2 diabetes (PMID: 22338105).
C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1.
CFP is a prognostic biomarker and correlated with immune infiltrates in Gastric Cancer and Lung Cancer.
Cell Death Dis
Tension of plus-end tracking protein Clip170 confers directionality and aggressiveness during breast cancer migration