CXCR1 Polyclonal antibody

CXCR1 Polyclonal Antibody for IP, WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (1)

Applications

WB, IP,ELISA

Conjugate

Unconjugated

Cat no : 55450-1-AP

Synonyms

C C, C C CKR 1, CD128, CD181, CDw128a, CKR 1, CMKAR1, CXC R1, CXCR 1, CXCR1, IL 8 receptor type 1, IL 8R A, IL8R1, IL8RA, IL-8RA, IL8RBA, interleukin 8 receptor, alpha



Tested Applications

Positive WB detected inJurkat cells
Positive IP detected inJurkat cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:200-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
Sample-dependent, check data in validation data gallery

Published Applications

WBSee 2 publications below

Product Information

55450-1-AP targets CXCR1 in WB, IP,ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name interleukin 8 receptor, alpha
Calculated molecular weight 40 kDa
Observed molecular weight 50 kDa
GenBank accession numberNM_000634
Gene symbol IL8RA
Gene ID (NCBI) 3577
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Aliquoting is unnecessary for -20oC storage.

Background Information

CXCR1, also named as CMKAR1, IL8RA and CD181, belongs to the G-protein coupled receptor 1 family. It is a receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. CXCR1binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. This antibody is specific to CXCR1.

Protocols

Product Specific Protocols
WB protocol for CXCR1 antibody 55450-1-APDownload protocol
IP protocol for CXCR1 antibody 55450-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
human

Cancer

The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3-induced dormant ovarian cancer xenografts.

Authors - Weiqun Mao
humanWB

Pharmacol Res

Sinomenine inhibits osteolysis in breast cancer by reducing IL-8/CXCR1 and c-Fos/NFATc1 signaling.

Authors - Yueyang Zhang
mouseWB

Cytokine

IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.

Authors - Zhihao Wang