DPYD Polyclonal antibody, PBS Only

• 

  WB analysis of mouse liver using 25690-1-AP (same clone as 25690-1-PBS)

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 25690-1-AP (DPYD antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25690-1-PBS in a different storage buffer formulation.

DPYD Polyclonal Antibody for WB, Indirect ELISA

Cat No. 25690-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

WB, Indirect ELISA

Synonyms

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Product Information

25690-1-PBS targets DPYD in WB, Indirect ELISA applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag20885

  Product name: Recombinant human DPYD protein

  Source: e coli.-derived, PET30a

  Tag: 6*His

  Domain: 1-173 aa of BC008379

  Sequence: MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATETLILAFSLMNHL

• Full Name: dihydropyrimidine dehydrogenase
• Calculated Molecular Weight: 1025 aa, 111 kDa
• Observed Molecular Weight: 111 kDa
• GenBank Accession Number: BC008379
• Gene Symbol: DPYD
• Gene ID (NCBI): 1806
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q12882
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy.