Anti-Mouse CD324 (E-cadherin) (DECMA-1)

CD324 (E-cadherin) Monoclonal Antibody for IF, FC

Host / Isotype

Rat / IgG1, kappa


Mouse, Human, Canine







Cat no : 65241-1-Ig


AA960649, cadherin 1, Cdh1, Ecad, L CAM, Um, UVO

Tested Applications

Positive IF detected inmouse colon tissue
Positive FC detected inMDCK cells

Recommended dilution

Immunofluorescence (IF)IF : 1:625-1:2500
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

65241-1-Ig targets CD324 (E-cadherin) in IF, FC applications and shows reactivity with Mouse, Human, Canine samples.

Tested Reactivity Mouse, Human, Canine
Host / Isotype Rat / IgG1, kappa
Class Monoclonal
Type Antibody
Immunogen Mouse embryonal carcinoma cell line PCC4 Aza RI
Full Name cadherin 1
GenBank Accession NumberBC098501
Gene Symbol Cdh1
Gene ID (NCBI) 12550
Conjugate Unconjugated
Form Liquid
Purification MethodAffinity purification
Storage Buffer PBS with 0.09% sodium azide.
Storage ConditionsStore at 2-8°C. Stable for one year after shipment.

Background Information

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. It has been regarded as a marker for spermatogonial stem cells in mice(PMID:23509752). E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.


Product Specific Protocols
IF protocol for CD324 (E-cadherin) antibody 65241-1-IgDownload protocol
FC protocol for CD324 (E-cadherin) antibody 65241-1-IgDownload protocol
Standard Protocols
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