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EI24 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 20456-1-AP

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Con: 26 μg/150 μl

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Tested Applications

Applications:
WB, ELISA
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EI24 Antibody WB HeLa cells 20456-1-AP

HeLa cells were subjected to SDS PAGE followed by western blot with 20456-1-AP(EI24 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours

Species specificity:
human, mouse, rat
Positive WB detected in:
HeLa cells, HT-1080 cells, L02 cells
Recommended dilution:
WB : 1:1000-1:4000
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
EI24 fusion protein Ag14169
Full name:
etoposide induced 2.4 mRNA
Calculated molecular weight:
340aa,39 kDa
Observed molecular weight:
40-45 kDa
GenBank accession number:
BC002390
Gene ID (NCBI):
9538
Gene symbol
EI24
Synonyms
EI24, etoposide induced 2.4 mRNA, p53 induced gene 8 protein, p53-induced factor Ei24, PIG8, TP53I8

Background

Ei24 is an ER-localized protein originally identified as a p53-induced proapoptotic gene in etoposide-treated NIH3T3 cells. It has been shown to be able to bind to the antiapoptotic protein Bcl-2 (PMID: 15781622), play a role in autophagy (PMID: 23074225), and induce growth arrest/apoptosis (PMID: 10594026). Ei24 can bind specifically to IMPβ1 and IMPα2 to impede their normal role in nuclear import (PMID: 24821838).


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