F9 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 21481-1-AP

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Con: 38 μg/150 μl

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Species specificity:
human, MOUSE

Positive WB detected in:
Tunicamycin treated HepG2 cells

Positive IHC detected in:
human liver cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
coagulation factor IX

Calculated molecular weight:
461aa,52 kDa

Observed molecular weight:
56 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
F9

Synonyms
Christmas factor, coagulation factor IX, F9, FIX, HEMB, PTC
Background

The F9 gene encodes coagulation factor IX, which circulates as an inactive zymogen until proteolytic release of its activation peptide allows it to assume the conformation of an active serine protease. Its role in the blood coagulation cascade is to activate factor X (F10) through interactions with calcium, membrane phospholipids, and factor VIII (F8). Factor IX and factor X both consist of 2 polypeptide chains referred to as the L (light) and H (heavy) chains. The H chain bears a structural resemblance to the polypeptide chain of the pancreatic serine protease trypsin (PRSS1). The L chain is covalently linked to the H chain by a single disulfide bond.


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