Product Information
31841-1-PBS targets FAAP100 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag36385 Product name: Recombinant human C17orf70 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 524-730 aa of BC117139 Sequence: PVATFLETCREPGSQPAGPASLRAEYLPPSVASIKVSAELLRAALKDGHSGVPLCCATLQWLLAENAAVDVVRARALSSIQGVAPDGANVHLIVREVAMTDLCPAGPIQAVEIQVESSSLADICRAHHAVVGRMQTMVTEQAAQGSSAPDLRVQYLRQIHANHETLLREVQTLRDRLCTEDEASSCATAQRLLQVYRQLRHPSLILL Predict reactive species |
| Full Name | chromosome 17 open reading frame 70 |
| Calculated Molecular Weight | 93 kDa |
| Observed Molecular Weight | 100 kDa |
| GenBank Accession Number | BC117139 |
| Gene Symbol | C17orf70 |
| Gene ID (NCBI) | 80233 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q0VG06 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
FA core complex associated protein 100 (FAAP100, also known as C17orf70) is a component of the Fanconi anemia (FA), which plays a role in the FA-associated DNA damage response network as well as regulates Fanconi anemia group D2 protein (FANCD2) monoubiquitination and the stability of the FA core complex (PMID: 17396147). FAAP100 deletion leads to FA pathway inactivation, increases TRCs and cotranscriptional R-loops, and contributes to the collapse of replication forks and the generation of DNA damage (PMID: 37580696).
