- Featured Product
- KD/KO Validated
FASTKD2 Polyclonal Antibody for IF, IP, WB, ELISA
Cat no : 17464-1-AP
FAST kinase domains 2, FASTKD2, KIAA0971
|Positive WB detected in||mouse heart tissue, transfected cells, mouse brain tissue|
|Positive IP detected in||mouse heart tissue|
|Positive IF detected in||COS7 cells, U2OS cells|
|Western Blot (WB)||WB : 1:200-1:1000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB|
|Immunofluorescence (IF)||IF : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
17464-1-AP targets FASTKD2 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, zebrafish|
|Host / Isotype||Rabbit / IgG|
|Immunogen||FASTKD2 fusion protein Ag11314|
|Full Name||FAST kinase domains 2|
|Calculated molecular weight||710 aa, 81 kDa|
|Observed molecular weight||73-75 kDa|
|GenBank accession number||BC001544|
|Gene ID (NCBI)||22868|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
FASTKD2(FAST kinase domain-containing protein 2) is also named as KIAA0971 and belongs to the FAST kinase family.A potential cleavage site of the 79 kDa FASTKD2 precursor protein by the mitochondrial matrix protease (MMP) is present between M52 and Q53 and predicts the mature imported protein from the FASTKD2 precursor to be composed of 642 amino acid residues for a MW of approximately 73 kDa(PMID: 18771761) and the clinical and MRI findings of the FASTKD2-associated disease are rather unusual for mitochondrial disorders.
J Cell Biochem
FASTKD2 promotes cancer cell progression through upregulating Myc expression in pancreatic ductal adenocarcinoma.
J Biol Chem
Role of FAST kinase domains 3 (FASTKD3) in post-transcriptional regulation of mitochondrial gene expression.
J Biol Chem
The Pseudouridine Synthase RPUSD4 is an essential component of Mitochondrial RNA Granules.
Mutations in FASTKD2 are associated with mitochondrial disease with multi-OXPHOS deficiency.
J Cell Sci
Mitochondrial Alkbh1 localises to mtRNA granules and its knockdown induces mitochondrial UPR in humans and C. elegans.
FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation.