GBP1 Monoclonal antibody

GBP1 Monoclonal Antibody for WB,ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human, pig, rat and More (1)

Applications

WB, IF,ELISA

Conjugate

Unconjugated

CloneNo.

2A10E8

Cat no : 67161-1-Ig

Synonyms

GBP 1, GBP1, GTP binding protein 1, HuGBP 1



Tested Applications

Positive WB detected inHeLa cells, human placenta tissue, HUVEC cells, pig spleen tissue, rat spleen tissue, HEK-293 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:5000-1:50000
Sample-dependent, check data in validation data gallery

Product Information

67161-1-Ig targets GBP1 in WB, IF,ELISA applications and shows reactivity with Human, pig, rat samples.

Tested Reactivity Human, pig, rat
Cited Reactivity human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen GBP1 fusion protein Ag7767
Full Name GTP binding protein 1
Calculated molecular weight 68 kDa
Observed molecular weight 68 kDa
GenBank accession numberBC002666
Gene symbol GBP1
Gene ID (NCBI) 2633
Conjugate Unconjugated
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Aliquoting is unnecessary for -20oC storage.

Background Information

Guanylate binding protein 1 (GBP1) belongs to the dynamin superfamily of large GTPases. The expression of GBP1 is induced by IFN and GBP1 is characterized by its ability to specifically bind guanine nucleotides such as GMP, GDP, and GTP and its ability to hydrolyze GTP to GDP and GMP. GBP1 is induced in response to type I and type II IFNs and as such plays a role in protective immunity against a spectrum of intracellular pathogens ranging from viruses to bacteria to protozoa, such as negative-strand RNA Rhabdovirus, vesicular stomatitis virus and the positive-strand RNA Picornovirus, encephalomyocarditis virus in cultured cells, the inhibition of Chlamydia trachomatis, Toxoplasma gondii, and Salmonella enterica.

Protocols

Product Specific Protocols
WB protocol for GBP1 antibody 67161-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB,IF

Front Immunol

GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung Cancer.

Authors - Yinnan Meng