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Product Information

17859-1-PBS targets GCS1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen GCS1 fusion protein Ag12321 Predict reactive species
Full Name mannosyl-oligosaccharide glucosidase
Calculated Molecular Weight 837 aa, 92 kDa
Observed Molecular Weight 80-92 kDa
GenBank Accession NumberBC028337
Gene Symbol GCS1
Gene ID (NCBI) 7841
RRIDAB_10694270
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ13724
Storage Buffer PBS only, pH 7.3.
Storage ConditionsStore at -80°C.

Background Information

MOGS (Mannosyl-oligosaccharide glucosidase), also known as GCS1, is the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor (PMID: 38187061). The resulting Glc(2)-Man(9)-GlcNAc(2) intermediate is then further modified by glucosidase II and several ER- and Golgi-resident mannosidases and glycosyltransferases, finally yielding a complex array of glycan structures (PMID: 3896128). MOGS has two isoforms, and it is located in the lumen of the endoplasmic reticulum.

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