NMDAR2B/GRIN2B Polyclonal antibody

GRIN2B Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF,ELISA

Conjugate

Unconjugated

Cat no : 19954-1-AP

Synonyms

GluN2B, GRIN2B, hNR3, NMDAR2B, NR2B, NR3



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Product Information

19954-1-AP targets GRIN2B in WB, IF,ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Calculated molecular weight 166 kDa
GenBank accession numberNM_000834
Gene symbol GRIN2B
Gene ID (NCBI) 2904
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

GRIN2B (also known as GluN2B or NMDAR2B) is a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. NMDA receptors are widely expressed in the central nervous system and play a major role in excitatory synaptic transmission and plasticity (PMID: 23223336). NMDA receptors large multi-subunit complexes arranged into heteromeric assemblies composed of four homologous subunits within a repertoire of over 10 different subunits: eight GluN1 isoforms, four GluN2 subunits (A-D) and two GluN3 subunits (A and B) (PMID: 21395862). Naturally occurring mutations within GRIN2B gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.

Publications

SpeciesApplicationTitle
ratWB

Toxicology

Role of astrocytes-derived d-serine in PFOS-induced neurotoxicity through NMDARs in the rat primary hippocampal neurons.

Authors - Ruijun Wang
ratWB,IF

Neurochem Int

Protective effects of EphB2 on Aβ1-42 oligomer-induced neurotoxicity and synaptic NMDA receptor signaling in hippocampal neurons.

Authors - Geng Dandan D
mouseWB

Brain Res

Central nervous system-specific knockout of Brg1 causes growth retardation and neuronal degeneration.

Authors - Li Deng
mouseWB

Front Cell Dev Biol

RAB39B Deficiency Impairs Learning and Memory Partially Through Compromising Autophagy.

Authors - Mengxi Niu
mouseWB

Front Cell Dev Biol

Profiling of Sexually Dimorphic Genes in Neural Cells to Identify Eif2s3y, Whose Overexpression Causes Autism-Like Behaviors in Male Mice.

Authors - Muxian Zhang