HPSE2 Polyclonal antibody, PBS Only

• 

  WB analysis of L02 using 21128-1-AP (same clone as 21128-1-PBS)

  L02 cells were subjected to SDS PAGE followed by western blot with 21128-1-AP (HPSE2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21128-1-PBS in a different storage buffer formulation.

• 

  WB analysis of L02 using 21128-1-AP (same clone as 21128-1-PBS)

  L02 cells were subjected to SDS PAGE followed by western blot with 21128-1-AP (HPSE2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21128-1-PBS in a different storage buffer formulation.

HPSE2 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 21128-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

heparanase 2, Hpa2, HPR2, Inactive heparanase-2

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Product Information

21128-1-PBS targets HPSE2 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: HPSE2 fusion protein Ag15526
• Full Name: heparanase 2
• Calculated Molecular Weight: 592 aa, 67 kDa
• Observed Molecular Weight: 54 kDa, 66 kDa
• GenBank Accession Number: BC112356
• Gene Symbol: HPSE2
• Gene ID (NCBI): 60495
• RRID: AB_10733344
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q8WWQ2
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

HPSE2 (heparanase 2) is a homolog of HPSE (heparanase 1). HPSE is an endo-β-glucuronidase that cleaves heparan sulfate proteoglycans (HSPGs), which are important components of the extracellular matrix and basement membranes. HPSE2, however, lacks intrinsic heparan sulfate-degrading activity. Instead, it binds to heparan sulfate with higher affinity than HPSE, thereby competing with HPSE for heparan sulfate binding and inhibiting HPSE's enzymatic activity. This competitive inhibition makes HPSE2 a crucial regulator of heparan sulfate metabolism.